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Episodes from This Podcast Will Kill You
Ep 205 Cancer Part 4: Where do things stand today?
For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re using this final installment in our cancer miniseries to show some appreciation. To grasp the impact that screening and prevention can have, we also need to consider the global landscape of cancer preval...
Ep 204 Cancer Part 3: How do we treat it?
A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple notebooks to delineate all of the various therapies currently in development. It is nothing short of a revolution. Of course, no revolution is perfect, and many cancer treatments are ineffective or carry risks of serious side effects. In part 3 of our cancer series, we delve into all facets of cancer treatment, from the history of their development to how they actually work. Tune in to learn ho...
Special Episode: Lawrence Ingrassia & A Fatal Inheritance
For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost hi...
Ep 203 Cancer Part 2: Why does it happen?
Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a cell cancerous are those that, under other circumstances, are beneficial, essential even, for an individual’s growth and survival. How is that possible? In the second installment in our series, we’re putting cancer under the microscope to consider the qualities that underlie a cancer cell’s success in our body. By placing cancer in an evolutionary framework, we can not only understand why canc...
Ep 202 Cancer Part 1: What is it?
Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowledge that will help make sense of this multifaceted disease. We begin our four-part series on cancer by asking a deceptively simple question: what is cancer? As we’ll discover over the course of these episodes, there is not one answer but many. After all, cancer is not one disease but many. In this first episode, we examine the clinical definitions of cancer - wh...
Special Episode: Jon Adams and Edmund Ramsden & Rat City
What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” experiments from the mid-20th century revealed a behavioral dark side that emerged as space grew increasingly limited, ultimately leading to complete population collapse. As headlines conveyed dire warnings about global overpopulation, Calhoun’s work served to reinforce those fears and shape our understanding of the importance of personal space. In this week’s TPWKY book club episode, Jon Adams and Edmund Ramsden join me to discus...
Ep 201 Poop Part 2: Flushed away
Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate sewer systems have revolutionized health and hygiene by whisking our poop far away where we don’t have to think about it. But that poop has gotta go somewhere, and eventually, not thinking about it isn’t going to be an option. Similarly, not thinking about our individual poop is asking for disaster, since what we produce can reveal a great deal about our gut and overall health. In thi...
Ep 200 Poop Part 1: How the sausage gets made
It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so, we’re going to bring it back into mind as we delve into the rich world of poop. This episode, the first of a two-part miniseries on poop, features a wide cast of characters all with some role in the production or management of poo, like our intestinal tract with its sphincters and microbiota, dung be...
Special Episode: Nicola Twilley & Frostbite
For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from how they taste to what we eat, refrigeration has dramatically - and quite recently - changed our relationship to food, our health, and the environment. As Nicola Twilley describes in Frostbite: How Refrigeration Changed our Food, Our Planet, and Ourselves, progress, as it so often does, comes at a cost. Twilley, who also cohosts the award-winning food podcast Gastropod, joins us in this...
Ep 199 Sleep Part 2: Predictably unpredictable
Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to public health guidelines. Why is that? Hypotheses abound, but many point the finger of blame at different aspects of modern society such as screen time, artificial light, a sedentary lifestyle. These narratives suggest that sleep in industrialized societies today is not just different but worse than in centuries past. Is that the truth? How did humans sleep in yesteryear, and what can that tell us...
Ep 198 Sleep Part 1: Sleeping with one eye open
Sleep is a universal experience. It’s not just the lion that sleeps tonight - it’s also the butterfly, the chicken, the jellyfish, the dog, the snake, the worm, and of course the human. What is this widespread physiological process whose spell we are all under? What purpose (or purposes) does it serve? Why do we sleep the way we do? These are just some of the questions we’re going to get into in this week’s episode, the first half of our two-parter on sleep. We break down the different components of sleep in humans before diving d...
Special Episode: Daniel Stone & American Poison
The widespread use of leaded gasoline in the 20th century led to one of the world’s biggest public health and environmental disasters, the effects of which are still present today. Since its development in the 1920s, leaded gasoline has been linked to premature death, cognitive impairment, and behavioral issues in millions around the globe. How was such a toxic substance permitted to be sold, despite the tireless efforts of industrial medicine warriors like Alice Hamilton? In American Poison: A Deadly Invention and the Woman Who Battled for Environmental Justice, award-winning author and historian Daniel Stone tells the story of...