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Episodes from The Journal of Clinical Psychopharmacology Podcast
Serotonin Synthesis Amplification to Augment the Therapeutic Efficacy of Serotonin Reuptake Inhibitor Antidepressants: Five Decades of Clinical Evidence
Serotonin reuptake inhibitors (SRIs) are a common treatment for major depressive disorder, but they are inadequate for many patients. An article published in the July-August 2026 issue reviews decades of evidence suggesting that their effects may be improved by developing medications, based on…
Should Bremelanotide Be Considered for the Treatment of Sexual Arousal and Desire Disorders in Men?
Bremelanotide (Vyleesi) was approved by the US Food and Drug Administration in 2019 as an on-demand subcutaneous injectable for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. An editorial in the May-June 2026 issue of the Journal of Clinical Psychopharmacology…
Current Clinical Psychopharmacology Integrated Practice: The Crisis in Teaching and Its Effects on Quality of Care
Why can it be challenging to find a psychiatrist well-trained in psychopharmacology? An editorial in the March-April 2026 issue of the Journal of Clinical Psychopharmacology suggests that the problem is not just an overall shortage of psychiatrists but also deficiencies in the depth of training,…
The Use of VMAT2 Inhibitors for Tardive Dyskinesia
In this podcast, Orges Alabaku discusses his article, "The Use of VMAT2 Inhibitors for Tardive Dyskinesia," which is published in the March-April 2026 issue of the Journal of Clinical Psychopharmacology. As Dr. Albaku notes, tardive dyskinesia (TD) is a potentially severe and often persistent…
Reduction of Loss of Control Eating in Youth With Attention-Deficit/Hyperactivity Disorder Following Initiation of Stimulant Medication: A Prospective Study
In youth, binge eating is often marked by loss of control eating (LOC-E), defined as difficulty stopping eating and persistent, compulsive food-seeking behaviors that occur even in the absence of physical hunger. In this podcast, Dr. Aaron Keshen discusses his article, titled, "Reduction of Loss of…
Esketamine and Quality of Life Improvement in Treatment-Resistant Depression Patients: A Real-World Clinical Study
Treatment-resistant depression (TRD) is a considerable clinical challenge. Esketamine, in conjunction with an oral antidepressant, is a potential treatment for TRD. In this podcast, Dr. Matteo Lupi discusses his article, "Esketamine and Quality of Life Improvement in Treatment-Resistant Depression…
Atomoxetine as a Viable ADHD Treatment in Breastfeeding Mothers: Evidence From Human Milk Pharmacokinetic Analysis
Atomoxetine is a selective norepinephrine reuptake inhibitor prescribed for the management of attention-deficit hyperactivity disorder (ADHD). In this podcast, Emily Yamada discusses her article "Atomoxetine as a Viable ADHD Treatment in Breastfeeding Mothers: Evidence From Human Milk…
Diet Drug Interactions: Achieving and Maintaining Ketosis As Adjunct to Psychotropic Polypharmacotherapy
As interest grows in the therapeutic potential of ketogenic diets for bipolar disorder, careful attention must be given to drug-diet interactions. Overlapping mechanisms between therapeutic ketosis and mood-stabilizing agents may offer opportunities for synergistic effects, but may also introduce…
Anticholinergic Equivalence in Psychotropic Medications: A Guide for Psychiatrists
In this podcast, Nicolas Badre, MD, and Eric Geier, MD, PhD, discuss their article, "Anticholinergic Equivalence in Psychotropic Medications: A Guide for Psychiatrists," which is published in the November-December 2025 issue of the Journal of Clinical Psychopharmacology. Anticholinergic side…
Fact Versus Fear: Antidepressants in Children and Adolescents
A presidential executive order early this year directed federal departments and agencies to address the issue of chronic disease in the United States, including "the prevalence of and threat posed by the prescription of selective serotonin reuptake inhibitors (SSRIs)," with a particular focus on…
How Does Positive Mental Health Affect Next-Step Treatment Outcomes in Treatment-Resistant Depression?
Many patients view the return of "positive mental health" (PMH) to be their most important goal of treatment for major depressive disorder (MDD). However, few studies have systematically measured PMH or prospectively examined the added value of considering PMH as a treatment predictor of outcomes.…
Variability in Response to Antidepressants
Antidepressants are in widespread use, but there is considerable variability in how patients respond, with some seeing substantial improvement while others respond only partially or not at all. In this podcast, Dr. Antonio E. Nardi discusses the many factors that underlie response rates, including…