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Episodes from The Journal of Clinical Psychopharmacology Podcast
Current Clinical Psychopharmacology Integrated Practice: The Crisis in Teaching and Its Effects on Quality of Care
Why can it be challenging to find a psychiatrist well-trained in psychopharmacology? An editorial in the March-April 2026 issue of the Journal of Clinical Psychopharmacology suggests that the problem is not just an overall shortage of psychiatrists but also deficiencies in the depth of training, supervision, and evaluations psychiatrists receive during their residencies. As a result, too few psychiatrists are truly prepared to offer integrated psychiatric treatment that melds psychotherapeutic and other treatments with modern psychopharmacology techniques. The editorial offers a variety of recommendations on how to improve the landscape. In this podcast, Dr. Julia Ann K...
The Use of VMAT2 Inhibitors for Tardive Dyskinesia
In this podcast, Orges Alabaku discusses his article, "The Use of VMAT2 Inhibitors for Tardive Dyskinesia," which is published in the March-April 2026 issue of the Journal of Clinical Psychopharmacology. As Dr. Albaku notes, tardive dyskinesia (TD) is a potentially severe and often persistent movement disorder associated with prolonged exposure to dopamine receptor-blocking agents, particularly antipsychotic medications. The only FDA-approved medications for TD are vesicular monoamine transporter 2 inhibitors (VMAT2-Is), valbenazine and deutetrabenazine, while another VMAT2-I medication, tetrabenazine, is used off-label. However, data about VMAT2-I use remain limited. In their study, Dr. Alabaku and c...
Reduction of Loss of Control Eating in Youth With Attention-Deficit/Hyperactivity Disorder Following Initiation of Stimulant Medication: A Prospective Study
In youth, binge eating is often marked by loss of control eating (LOC-E), defined as difficulty stopping eating and persistent, compulsive food-seeking behaviors that occur even in the absence of physical hunger. In this podcast, Dr. Aaron Keshen discusses his article, titled, "Reduction of Loss of Control Eating in Youth With Attention-Deficit/Hyperactivity Disorder Following Initiation of Stimulant Medication: A Prospective Study." In their article, the authors describe a prospective observational study that aimed to examine changes in LOC-E over a 3-month period in youth with comorbid attention-deficit/hyperactivity disorder and LOC-E who initiated stimulant medication. <p...
Esketamine and Quality of Life Improvement in Treatment-Resistant Depression Patients: A Real-World Clinical Study
Treatment-resistant depression (TRD) is a considerable clinical challenge. Esketamine, in conjunction with an oral antidepressant, is a potential treatment for TRD. In this podcast, Dr. Matteo Lupi discusses his article, "Esketamine and Quality of Life Improvement in Treatment-Resistant Depression Patients: A Real-World Clinical Study." The prospective study described in the report explores the long-term effects of esketamine therapy on subjective quality of life in adults with TRD. The other contributing authors are Alessandro Carano, Tiziano Acciavatti, Stefano Marini, Marco Palmucci, Elicio Marinucci, Enrico Paolini, Alessandro Gentile, Angelomarco Barioglio, Marco Giri, Domenico De Berardis, and Giovanni M...
Atomoxetine as a Viable ADHD Treatment in Breastfeeding Mothers: Evidence From Human Milk Pharmacokinetic Analysis
Atomoxetine is a selective norepinephrine reuptake inhibitor prescribed for the management of attention-deficit hyperactivity disorder (ADHD). In this podcast, Emily Yamada discusses her article "Atomoxetine as a Viable ADHD Treatment in Breastfeeding Mothers: Evidence From Human Milk Pharmacokinetic Analysis." In their article, Yamada and her colleagues present data showing that there is minimal transfer of atomoxetine in breast milk, suggesting that maternal atomoxetine use poses a very low risk to breastfed infants, making it a suitable choice for medication management of ADHD in lactating women. The other contributing authors are Shraddha Trehan, Amy Stark, Kaytlin K...
Diet Drug Interactions: Achieving and Maintaining Ketosis As Adjunct to Psychotropic Polypharmacotherapy
As interest grows in the therapeutic potential of ketogenic diets for bipolar disorder, careful attention must be given to drug-diet interactions. Overlapping mechanisms between therapeutic ketosis and mood-stabilizing agents may offer opportunities for synergistic effects, but may also introduce risks related to altered pharmacokinetics, pharmacodynamics, and additive toxicities. In this podcast, Dina N. Ali, MD, and Jonathan Leung, PharmD, discuss the complex picture of trying to optimize treatment outcomes while many research questions are yet to be answered. Ali and Leung are authors of the commentary, "Diet Drug Interactions: Achieving and Maintaining Ketosis As Adjunct to Psychotropic...
Anticholinergic Equivalence in Psychotropic Medications: A Guide for Psychiatrists
In this podcast, Nicolas Badre, MD, and Eric Geier, MD, PhD, discuss their article, "Anticholinergic Equivalence in Psychotropic Medications: A Guide for Psychiatrists," which is published in the November-December 2025 issue of the Journal of Clinical Psychopharmacology. Anticholinergic side effects from psychotropic medications are common and can lead to significant adverse events, including cognitive impairment and falls, particularly in vulnerable populations like the elderly. The cumulative anticholinergic burden from multiple medications is a critical concern associated with poorer clinical outcomes. Quantifying this burden is essential for safer prescribing. For their article, they developed a table to provide a...
Fact Versus Fear: Antidepressants in Children and Adolescents
A presidential executive order early this year directed federal departments and agencies to address the issue of chronic disease in the United States, including "the prevalence of and threat posed by the prescription of selective serotonin reuptake inhibitors (SSRIs)," with a particular focus on youth. In this podcast, Dr. Jeffrey R. Strawn discusses his editorial, "Fact Versus Fear: Antidepressants in Children and Adolescents," which is published in the September-October 2025 issue of the Journal of Clinical Psychopharmacology. In the editorial, Dr. Strawn and his coauthor, Dr. John T. Walkup, write that the framing of the issue...
How Does Positive Mental Health Affect Next-Step Treatment Outcomes in Treatment-Resistant Depression?
Many patients view the return of "positive mental health" (PMH) to be their most important goal of treatment for major depressive disorder (MDD). However, few studies have systematically measured PMH or prospectively examined the added value of considering PMH as a treatment predictor of outcomes. In this podcast, Dr. Somaia Mohamed discusses her article, "How Does Positive Mental Health Affect Next-Step Treatment Outcomes in Treatment-Resistant Depression? A VAST-D Report." Dr. Mohamed and her coauthors found that high PMH scores at baseline were associated with a greater chance of remission. The article is published in the...
Variability in Response to Antidepressants
Antidepressants are in widespread use, but there is considerable variability in how patients respond, with some seeing substantial improvement while others respond only partially or not at all. In this podcast, Dr. Antonio E. Nardi discusses the many factors that underlie response rates, including psychological factors, personality traits, and medication adherence. There are also some mood conditions such as demoralization that may seem to resemble depression but do not meet all the clinical criteria. Recognizing these different emotional states is crucial for both individuals and clinicians in the treatment of low mood disorders. Dr. Nardi...
A Systematic Review to Determine if Family History of Response to Medication Predicts Outcome in Mood Disorders
Examining a patient's family history of medication response is a commonly used method to guide physicians in treatment selection. Though it is widely recommended, there are no published reviews that assess the validity of this approach when treating patients with affective disorders. In this podcast, authors Jeffrey J. Rakofsky, Michael J. Lucido, and Boadie W. Dunlop of the Department of Psychiatry and Behavioral Sciences at Emory University discuss their article, "A Systematic Review to Determine if Family History of Response to Medication Predicts Outcome in Mood Disorders," which is published in the July-August 2025 issue of the Journal of Clinical...
How Does Drug Company Marketing Affect Physician Prescribing?
There is considerable evidence that marketing affects physician prescribing practices, even though physicians themselves may not feel that they are influenced. In a thought-provoking editorial, Dr. Jeffrey A. Mattes explores how e-prescribing systems may be one pathway through which pharmaceutical messaging may shape prescribing behavior. In this podcast, Dr. Mattes discusses his editorial, "How Does Drug Company Marketing Affect Physician Prescribing?" which is published in the July-August 2025 issue of the Journal of Clinical Psychopharmacology. doi: 10.1097/JCP.0000000000002030