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Episodes from Extend Podcast with Darshan Shah, MD
169. Natalie Lefevre: How to Find the Toxins Blocking Your Body's Ability to Heal
You can do the supplements, the IVs, the sauna, the clean eating, and the wellness routine, but if your body is still being exposed to toxins every day, you may be cleaning up a mess while the tap is still running. That is what makes toxic load so frustrating. It can hide in your water, food, air, dental work, travel habits, mold exposure, heavy metals, PFAS, pesticides, microplastics, and even the products you use daily, while standard labs never show the full picture. In this episode of Extend, I sit down with Natalie Lefevre to talk about...
168. Peter Crone: Why You Can't Access True Vitality Until You Free Your Mind
When we talk about health, longevity, and performance, the conversation often starts with the body. We look at biomarkers, sleep, nutrition, exercise, recovery, and protocols, hoping that if we get enough of the physical pieces right, we will finally feel better, stronger, and more alive. Yet there is another layer that can quietly shape everything from the way we handle stress to the way we heal, lead, love, perform, and experience our own potential. In this episode of Extend, I sit down with Peter Crone to explore why true vitality is not only about what is happening...
167. Dr. Amie Hornaman: The Thyropause Problem: Why So Many Women Feel Off in Midlife Despite "Normal" Labs
Have you entered midlife and started gaining weight, feeling exhausted, waking up foggy, losing motivation, or noticing your mood shift while your labs keep coming back "normal"? For a lot of women over 40, that answer does not bring relief because they still feel off, and this episode explains why thyropause, the midlife decline in thyroid function, is so often missed, dismissed, or mistaken for aging, burnout, depression, or menopause. We dive deeper into this in the Extend Podcast with Dr. Darshan Shah with Dr. Amie Hornaman. We break down why TSH alone is not enough, how thyropause...
166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity
If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like something cosmetic, something you maintain for how it looks. But your skin is your largest organ, it has its own biological age, and if you are not supporting it properly, it can become a constant source of inflammation and damage that goes far beyond appearance. We dive deeper into this in Extend with Carolina Reis de Oliveira, PhD. We also break down why most skincare products are not b...
165. Cynthia Thurlow: The Menopause Gut - Why Healing Your Hormones Starts With Healing Your Gut
The gut and hormones have always been treated as two completely separate conversations in medicine, and that disconnect is quietly behind some of the most frustrating symptoms women experience in midlife. From bloating and brain fog to autoimmune conditions and weight that will not move, the answers have been there all along, hiding in a connection nobody thought to make. We dive deeper into this in the Extend Podcast with Cynthia Thurlow. We also talk about why perimenopause is the ultimate litmus test of how well you have been living your life, why every woman deserves a...
164. SXSW Panel: How To Actually Take Control Of Your Health In 2026 and Beyond
A lot of us are doing everything we can to stay healthy, taking supplements, wearing trackers, getting our labs done, and still ending up sick. And if you are like most people, you probably thought that was on you, that you were not disciplined enough, not consistent enough, or simply not doing the right things, but that is not the case. The system we have been relying on was never designed to keep us well in the first place, and expecting the Western medical system to manage your long term health is like expecting a fire department to landscape...
163. Steve Chua: How Your Identity Is Either Healing Or Destroying Your Health
Most high performing executives will spend thousands optimizing their glucose levels, their sleep, and their body composition without ever stopping to ask why none of it makes them feel any better. The answer almost never lives in their labs and it almost never lives in their training program. It lives in the identity they built their entire career on top of, and the silent narrative driving every decision they make, that tells them their worth is only as good as their last result. In this episode of Extend, I sat down with Steve Chua to explore the...
162. Dr. Meredith Broderick: What An Undiagnosed Sleep Disorder Is Quietly Doing To Your Brain And Body
A lot of people are walking around exhausted, foggy, moody, and struggling with their cardiovascular health blaming stress, diet, age, and everything in between, never once considering that the real culprit might be happening in the eight hours they are not even awake for. And in children, what is being labeled as ADHD and treated with medication could in many cases simply be an undiagnosed sleep disorder that nobody thought to look for. In this episode of Extend, I sit down with Dr. Meredith Broderick for a conversation that is going to completely reframe the way you...
161. McCall McPherson: Why Your Thyroid Is Being Undertested And Undertreated
Fatigue, brain fog, weight gain, hair loss, low libido, high cholesterol, and a doctor who keeps telling you your labs look normal. For the millions of people walking around with an undetected or poorly managed thyroid condition, this is not just a frustrating experience but a dangerous one. Because what their doctor never told them is that the most important thyroid marker, the one that actually powers every cell in the body, is only being checked 4% of the time, which means the test they are relying on to rule out a thyroid problem is missing it almost every single...
160. Dr. Kara Fitzgerald on Biological Age, Epigenetic Clocks, and the Future of Aging Reversal
Biological aging is no longer just a concept tied to time. It is something we can now measure, track, and influence through data, lifestyle, and targeted interventions that directly impact how our cells function and age. In this episode of Extend, we sit down with Dr. Kara Fitzgerald, functional medicine leader, researcher, and author, to unpack how diet and lifestyle can directly influence epigenetics and biological age. We break down the difference between chronological and biological aging, how epigenetic clocks work across organs and systems, and why aging may be driven by both environmental exposures and deeper...
159: Dr. Anurag Singh: Urolithin A, Mitophagy, and Mitochondrial Health
Mitochondrial decline is one of the most overlooked drivers of aging, impacting energy, muscle function, cognitive performance, and immune resilience long before symptoms become obvious. Many of the changes we associate with aging may actually stem from a loss of cellular efficiency and the body's ability to renew itself. In this episode of Extend, I sit down with Dr. Anurag Singh, Chief Medical Officer at Timeline, to unpack the science behind urolithin A and how mitochondrial health shapes longevity. We break down how the gut microbiome influences cellular function, why mitophagy declines with age, and what clinical...
158. Dr. Kavin Mistry: Primal Health Design, Biological Aging, and Reconnecting with Human Biology
Modern life is quietly accelerating biological aging, from posture and movement patterns to sleep disruption, chronic stress, and constant digital stimulation. Many of the symptoms people experience daily, like pain, fatigue, brain fog, and disconnection, may reflect a deeper misalignment with how the human body was designed to function. In this episode of Extend, I sit down with Dr. Kavin Mistry, board-certified neuroradiologist and author of Primal Health Design, to unpack how modern lifestyles are reshaping our biology and accelerating aging. We break down how posture, movement, circadian rhythm, nutrition, and environment influence brain and spine health...